Metabolite Structural ID
Rapid identification and deconvolution of small molecules and metabolites is achieved using advanced NMR technology. These methods allow for the structural characterization of low-concentration metabolites and other small molecules, providing critical support for cutting-edge drug research and discovery.
All Metabolite ID NMR experiments are performed on 700 or 800 MHz NMR spectrometers equipped with HCN or HCNF cryoprobes, allowing for shorter acquisition times and lower sample concentrations without compromising data quality.
At Maratech NMR Solutions, we conduct all necessary NMR experiments to elucidate key structural elements of both the parent compound and its metabolites, including:
-
1D ¹H
-
1D/2D NOESY
-
1D ¹⁹F
-
2D ¹H COSY
-
1D/2D TOCSY
-
2D ¹H–¹³C HSQC
-
1D/2D ROESY
-
2D ¹H–¹³C HMBC
-
HSQC-ADTOXY
By comparing the spectra of the parent compound and the metabolite, we can unequivocally identify the metabolite structure, providing precise insights for drug development and research.