Protein Targeted Therapeutics
By combining cutting-edge NMR experiments with modern high-field spectrometers equipped with cryogenically cooled probes, we partner with clients to rapidly and efficiently deconvolute complex chemical and biological interactions—overcoming critical bottlenecks in research and discovery.
Protein-Targeted NMR
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NMR experiments can be tailored to specific biomolecules to elucidate ligand–target interactions under physiologically and biologically relevant conditions. These powerful methods enable the identification of ligand binding sites while also monitoring macromolecular dynamics as a function of ligand engagement.
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At Maratech NMR Solutions, our Protein-Targeted Therapeutics capabilities include:
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Conformational and structural analysis of protein targets
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Ligand binding site identification
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Kinetics and dynamics studies of ligand binding
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Structure–Activity Relationship (SAR) analysis
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Dissociation constant (Kd) determination for affinity assessment
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Complete NMR-based 3D structure determination
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Natural abundance and isotopically labeled target protein production
