Our ligand binding capabilities include small molecule, protein, nucleic acid, peptide and protein-protein interactions.

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• Ligand-observe methods (1D e.g. STD/ waterLOGSY/ CPMG)

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• ​These type of experiments focus on the ligand's spectral properties and have no target size limitations

• Usually involve single- dimension experiments that are fast, sensitive and require relatively small amounts of both target and compound

• Provide a yes or no answer to ligand binding, but can also provide information on the ligand-target interaction

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• Target observe methods (2D eg. HSQC/HMQC)​​​

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• These type of experiments focus on the targets spectral properties and do have size limitations

• The target in question usually requires 15N-(selective or uniform) labeling

• The results can provide ligand binding site identification and target conformational change that result upon ligand binding

• 2D NMR methods are required

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• Binding constant determination (Kd)

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• By using various 1D and 2D methods, the solution based ligand Kd can be determined

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